The EMHG has published guidelines about the criteria to classify mutations as diagnostic (causative). These guidelines can be downloaded [PDF / 74 KB].
Presence of a diagnostic (causative) mutation allows for the diagnosis of MH susceptibility. Absence of such mutation(s) do not allow for any diagnosis. MH can only be excluded by contracture testing. See EMHG guidelines on genetic testing for MH susceptibility [PDF / 79 KB].