Clinical advice provided by the diagnostic laboratory director remains the responsibility of the individual physician. All available information should be taken into account, including clinical evaluation as well as IVCT results. Muscle histopathology, serum biochemistry and molecular genetic analysis may provide additional information. However, in general all patients with any subtype of MHS IVCT classification should be considered at risk of developing malignant hyperthermia under anaesthesia. Laboratory MHN diagnosis is good evidence that the patient is not at increased risk of developing malignant hyperthermia. An MHN tested individual cannot transmit MH risk to their offspring.